教师名录

孙占奎

长聘教轨副教授

 

电话:021-34208590
邮箱:zksun@sjtu.edu.cn
主页:实验室 : beat365 7-501,503,504

孙占奎博士本科毕业于南京大学,之后进入中科院上海有机化学研究所攻读博士学位,师从马大为院士。博士毕业后赴美国留学,主要在密西根大学安娜堡分校从事有机化学以及药物化学的研究工作。目前是beat365副院长,博士生导师。

主要成果 / 奖励
相继获得2017年国家青年特聘专家、2018年江苏省双创计划领军人才等多个人才项目的支持。
获聘上海交通大学“致远学者研究计划”导师。
针对新的药物作用靶点进行药物设计与开发,聚焦抗感染及抗肿瘤药物开发;
多肽及蛋白质化学修饰,及抗体偶联药物开发;
新型荧光标记方法。

涵盖药物化学、计算机辅助药物设计、化学生物学、有机化学等研究领域。

讲授课程:
本科生:《药物化学实验》、《药物化学》、《药物设计与开发Ⅰ(中药及化学药)》

课题组获得国家以及上海交通大学支持,经费充裕,实验室新近装修,热忱欢迎研究生或者博士后人员加入!
课题组最新研究成果:
(1) Direct synthesis of unnatural amino acids and modifications of peptides via LADA strategy. Chinese Chemical Letters, 2024, 35, 108553.
(2) Design and Synthesis of Novel Near-Infrared Fluorescence Probes Based on an Open Conformation of Cytochrome P450 1B1 Complex for Molecular Imaging of Colorectal Tumors. J. Med. Chem., 2023, in press.
(3) LADA strategy for the synthesis of unnatural amino acids and direct modifications of peptides. SCIENCE CHINA Chemistry, 2023, 66, 1788.
(4) Decarboxylative oxidation-enabled consecutive C-C bond cleavage. Nature Communications, 2022, 13,7061.
(5) Three-component radical homo Mannich reaction, Nature Communications, 2021, 12, 1006.
(6) Visible-light induced metal-free cascade Wittig/hydroalkylation reactions, Green Chemistry, 2021, 23: 1638.
(7) A mild, general, and metal-free method for site-specific deuteration induced by visible light
using D2O as the source of deuterium atoms, Green Chemistry, 2020, 22, 669-672.
(8) Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors. Eur. J. Med. Chem., 2020, 187, 111938.
(9) Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. Eur. J. Med. Chem., 2019, 165, 160-171.
(10) Design, synthesis, and biological evaluation of cytochrome P450 1B1 targeted molecular imaging probes for colorectal tumor detection. J. Med. Chem. 2018, 61, 10901-10909.

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